Related Pages. Dermal exposures: An abnormal pigmentation of the skin may be seen. Specialist to Consult We are leading the charge towards a better future. Norepinephrine should be considered in cases of resistant shock. [Medline]. Arsine Gas. Both intravenous mannitol and urinary alkalinization have anecdotal value. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. Four patients with acute arsine gas poisoning were admitted to the Sverdlovsk Regional Poisoning Treatment Centre during 2014–2015, three of them were involved into the same exposure. 5. [emergency.cdc.gov] Three months later he again had aplastic anemia, and the urine once more contained considerable amounts of arsenic. Despite its lethality, it finds some applications in the semiconductor industry and for the synthesis of organoarsenic compounds. Liver function tests indicated all sero-floccula tion tests to be abnormal. The CDC case definition of arsine poisoning includes the following: [9] Suspected: A case in which a potentially exposed person is being evaluated by health care worker or public health officials for poisoning by a particular chemical agent, but no specific credible threat exists. Method. Arsine poisoning treatment should focus on restoring RBC concentrations, maintaining renal function, electrolyte replacement and aggressive supportive care. The treatment depends on the type and stage of the arsenic poisoning. [18]. Initially, there is painless hemoglobinuria, dizziness, weakness, nausea, vomiting, abdominal cramping and tenderness. Arch Environ Health. Download Citation | Treatment of patients with acute arsine poisoning | Objective: To study the characteristics of patients with acute arsine poisoning and its possible treatments. [Medline]. the L.D.100. If hemolysis is present, the patient/victim must be observed up to 72 hours for signs of renal failure. Paresthesias and peripheral neuropathy are common symptoms of a work-related arsenic poisoning. 5. 2002 • Inhalation exposures: The signs and symptoms of acute poisoning are consistent with acute and massive hemolysis. There are no published guidelines specific to the treatment of arsine poisoning during pregnancy. Data from patients with severe acute arsine poisoning, treated with plasma exchange from December 2000 to December 2005 were collected and analyzed. Methods. Treatment is symptomatic and consists of measures to support respiratory, vascular, and renal function. Available at https://www.atsdr.cdc.gov/MMG/MMG.asp?id=1199&tid=278. Ann N Y Acad Sci. The best way to treat the condition is to eliminate arsenic exposure. Acute kidney injury by arsine poisoning: the ultrastructural pathology of the kidney. Victims who have exposure only to arsine gas do not need decontamination. Ocular exposures: Red staining of the conjunctiva may be an early sign of arsine poisoning. 1986 May. Arsine Poisoning is outlined here in terms of description, signs, symptoms, lab testing, imaging studies, diagnosis, and treatment Arsine (IUPAC name: arsane) is an inorganic compound with the formula As H 3. 2007 Sep. 45(6):721-7. Kermit D Huebner, MD, FACEP is a member of the following medical societies: Alpha Omega Alpha, American Academy of Emergency Medicine, Association of Military Surgeons of the US, Society for Academic Emergency Medicine, Society of United States Air Force Flight SurgeonsDisclosure: Nothing to disclose. [12]. Contact the blood bank and hematologist regarding exchange transfusion. It is considered a possible chemical agent in chemical warfare. 2. This website also contains material copyrighted by 3rd parties. Renal damage from industrial arsine poisoning. It is a nonirritating gas with a mild odor (odorless at low doses) that is used in the semiconductor and metals refining industries. Diseases & Conditions, encoded search term (Arsine Poisoning) and Arsine Poisoning, Anemia of Chronic Disease and Kidney Failure, Online Misinformation Fuels a FightOver Folic Acid, Higher Red-Cell Transfusion Limit for Preemies Offers No Survival, Developmental Benefit, Top 10 Gastroenterology Articles Provide Essential Guidance, Hidden Diagnoses: From Einstein to Luther, JFK to Evita, Don't Use N95 Masks for More Than 2 Days, Research Suggests, A 30-Year-Old Man With Hallucinations After a House Party, Lower Back Pain: NSAID + Muscle Relaxant No Better Than NSAID + Placebo, Add Delirium to Checklist of COVID-19 Symptoms in Seniors. Install a carbon monoxide detector in sleeping areas and enclosed spaces, including helm positions. Hsu LI, Hsieh FI, Wang YH, Lai TS, Wu MM, Chen CJ, et al. Exchange transfusion is the treatment of choice for patients with severe hemolysis. In particular, paralytic shellfish poisoning and puffer fish poisoning can cause death within hours after consuming the toxins and may require immediate intensive care. Chelating agents (eg, 2,3-dimercaptopropanol, British antilewisite [BAL]) have not been shown to be of benefit in acute arsine toxicity. Cases of contact with liquid ( compressed gas ), gently wash frosted skin water... Responds well to antihistamines ( H1-receptor blockers, although H2-receptor blockers may also provide some ). Providing supportive medical care in a hospital setting to anyone although H2-receptor blockers may also arsine poisoning treatment benefit... ' airway, breathing, and renal function with normal saline ( )... Poisoning have important neurological symptoms—ciguatera, tetrodotoxin poisoning, or arsenicosis, happens when a takes. Consult a nephrologist for hemodialysis in patients with severe acute arsine poisoning can lead to acute renal tubular necrosis ultimately... 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